Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT

TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a pr...

Source: Cell Communication and Signaling - February 8, 2021 Category: Molecular Biology Authors: Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao and Yanfeng Gao Tags: Research Source Type: research