Mitochondrial DNA copy number may be associated with attention deficit/hyperactivity disorder severity in treatment: a one-year follow-up study.

CONCLUSIONS: There may be a relationship between decreased ADHD severity with treatment and positive effects of mitochondrial functions. Mitochondrial dysfunction may play a role in pathophysiology of ADHD. KEY POINTS This was the first study to follow up ADHD patients in order to investigate mitochondrial dysfunction by measuring mtDNA copy numbers 1 year after the initial measurements. mtDNA copy number, one of the best markers of mitochondrial dysfunction, did not change in ADHD patients over a period of 1 year regardless of treatment. Mitochondrial dysfunction may play a role in the pathophysiology of ADHD, where it may be involved with or without treatment. In the treated group, there was an association between decreased ADHD severity and reduced mtDNA copy numbers. There may be a relationship between decreased ADHD severity with treatment and the positive effects of mitochondrial functions. PMID: 33555215 [PubMed - as supplied by publisher]
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research