Diagnosis and management of secondary causes of steatohepatitis

The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and metabolic diseases, intestinal diseases, endocrine disorders and drugs may cause hepatic steatosis reminiscent of NAFLD, aggravate obesity-/metabolic syndrome-associated lipid deposition, or coexist with NAFLD. In contrast to NAFLD, therapeutic interventions are available for many secondary causes of NAFLD. Accordingly, secondary causes of fatty liver disease should be considered during the diagnostic workup of patients with fatty liver disease, and treatment of the underlying disease should be started to halt disease progression.

Source: Journal of Hepatology - February 9, 2021 Category: Gastroenterology Authors: Roman Liebe, Irene Esposito, Hans H. Bock, Stephan vom Dahl, Jan Stindt, Ulrich Baumann, Tom Luedde, Verena Keitel Tags: Review Source Type: research