Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis

ConclusionTrip regulates macrophage polarization through miR-449a/NLRP3 axis and the STAT3/NF- κB pathway to mitigate GA. The elucidation on the molecular mechanism of Trip in GA may provide theoretical guidance for clinical therapy of GA.

Source: Inflammation Research - February 9, 2021 Category: Research Source Type: research