Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy

This study reports the results of a monocentric prospective analysis conducted with the aim of evaluating the impact of XRCC1rs25487, XRCC3rs861539, XRCC3rs1799794, RAD51rs1801320 and GSTP-1rs1695 single nucleotide polymorphisms (SNP) on patients with high-grade glioma treated with concomitant radio-chemotherapy. From October 2010 to August 2019, a total of 75 patients aged ≥18 years, with histological diagnosis of high-grade glioma, isocitrate dehydrogenase (IDH) 1/2 wild type and treated with radio-chemotherapy and sequential chemotherapy with temozolomide (TMZ) were prospectively recruited. The local ethic committee approved this study (Comitato Etico di Area Vas ta Nord Ovest [CEAVNO]; protocol 3304/2011). After a median follow up of 25 months (range: 7–98 months), median progression-free survival (PFS) and overall survival (OS) were 11 months (CI95%: 8–14 months) and 18 months (CI95%: 15–21 months), respectively. In univariate and multivariate Cox regression analysis, a statistically significant association with PFS and OS was found with XRCC3rs1799794 SNP. The study suggests that XRCC3rs1799794 SNP can be associated with different PFS and OS in glioblastoma patients treated with radio-chemotherapy.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research