The prognostic implications of perioperative endogenous hydrogen sulfide and nitric oxide levels in children with congenital heart disease complicated by pulmonary arterial hypertension

Conclusions: Endogenous H2S and NO levels are closely associated with CHD-PAH incidence, and there is a correlation between endogenous H2S levels and the postoperative prognosis of CHD in children. Higher H2S concentrations seem to correspond to better patient prognosis, and as such these values can be used as a prognostic index at an early time point. These values can additionally guide treatment efforts and improve outcomes among children with CHD-PAH.What is Known:•Hydrogen sulfide and nitric oxide are both vasodilating factors.•Hydrogen sulfide and nitric oxide can regulate pulmonary vascular remodeling, which is closely related to the occurrence and prognosis of pulmonary arterial hypertension.What is New:•This study was designed to explore the relationship between short-term prognostic indexes and hydrogen sulfide and nitric oxide levels, in an effort to provide a frame of reference for the postoperative monitoring and treatment of children with congenital heart disease complicated by pulmonary arterial hypertension.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research