Long Non-coding RNAs in Parkinson's Disease.

Long Non-coding RNAs in Parkinson's Disease. Neurochem Res. 2021 Feb 05;: Authors: Xin C, Liu J Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder and is associated with a range of motor and non-motor clinical symptoms. The underlying molecular pathogenesis of PD involves a variety of pathways and mechanisms, including α-synuclein proteostasis, mitochondrial dysfunction, oxidative stress, autophagy and apoptosis, neuroinflammation, and epigenetic regulation. Long non-coding RNAs (lncRNAs) are involved in the regulation of multiple pathological processes of PD. In this review, we provide an overview of large-scale studies on lncRNA expression profiling in PD patients and models, as well as highlight the impacts of lncRNAs on the pathogenesis of PD, which could provide basic information regarding the putative lncRNA-based biomarkers and therapeutic targets for the early diagnosis and treatment strategies for PD. PMID: 33544326 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33544326?dopt=Abstract

Source: Neurochemical Research - February 5, 2021 Category: Neuroscience Authors: Xin C, Liu J Tags: Neurochem Res Source Type: research