Sequence analysis of the DA domain of glycoprotein E2 of pestiviruses isolated from beef cattle in Southern Brazil

In this study, we analyzed the E2 DA domain of 43 pestiviruses from Southern Brazil. The isolates were identified asBovine viral diarrhea virus (BVDV) subtypes 1a  and 1b or BVDV-2b. Compared to reference strains, the BVDV-1 and -2 isolates had four and two mutations in the DA domain, respectively. All BVDV-2 isolates had a deletion of residues 724 and 725. All mutated amino acids in the BVDV isolates had the same aa substitution, and all were in previousl y identified antibody binding sites. It is possible that an immunity-mediated selection is acting on the pestiviruses circulating in Southern Brazil.
Source: Archives of Virology - Category: Virology Source Type: research