Conventional Nanosized Drug Delivery Systems for Cancer Applications.

Conventional Nanosized Drug Delivery Systems for Cancer Applications. Adv Exp Med Biol. 2021;1295:3-27 Authors: Vergallo C, Hafeez MN, Iannotta D, Santos HA, D'Avanzo N, Dini L, Cilurzo F, Fresta M, Di Marzio L, Christian C Abstract Clinical responses and tolerability of conventional nanocarriers (NCs) are sometimes different from those expected in anticancer therapy. Thus, new smart drug delivery systems (DDSs) with stimuli-responsive properties and novel materials have been developed. Several clinical trials demonstrated that these DDSs have better clinical therapeutic efficacy in the treatment of many cancers than free drugs. Composition of DDSs and their surface properties increase the specific targeting of therapeutics versus cancer cells, without affecting healthy tissues, and thus limiting their toxicity versus unspecific tissues. Herein, an extensive revision of literature on NCs used as DDSs for cancer applications has been performed using the available bibliographic databases. PMID: 33543453 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research