Progressive gammopathy and coagulopathy in a young English bulldog.

Progressive gammopathy and coagulopathy in a young English bulldog. Can Vet J. 2021 Feb;62(2):160-166 Authors: Grady JL, Avery A, Moore AR, Harris LJ, Kakar N, Rout ED Abstract A restricted polyclonal or biclonal gammopathy resulting in bleeding tendencies was diagnosed in a young, neutered male English bulldog with concurrent splenomegaly, anemia, and severe elevations in IgM and, to a lesser degree, IgA immunoglobulins. There was a positive clinical response to treatment with prednisone and chlorambucil. This case bears similarity to a recently published syndrome of polyclonal gammopathy that is not neoplastic in origin in this breed. Key clinical message: The current case describes the management and clinical course of a recently described syndrome of polyclonal gammopathy in English bulldogs. PMID: 33542555 [PubMed - in process]
Source: The Canadian Veterinary Journal - Category: Veterinary Research Authors: Tags: Can Vet J Source Type: research