College of American Pathologists Tumor Regression Grading System for Long-term Outcome in Patients with Locally Advanced Rectal Cancer.

CONCLUSIONS: AJCC/CAP TRG system, an accurate prognostic surrogate, appears ideal for further strategizing adjuvant chemotherapy for LARC.
IMPLICATIONS FOR PRACTICE: NCCN recommend the AJCC/CAP TRG 4-category system to evaluate the pathologic response to neoadjuvant treatment for patients with locally advanced rectal cancer. However, the clinical significance of AJCC/CAP TRG system had not yet been clearly addressed. In this study, we found for the first time that any 2 of 4 AJCC/CAP TRG categories had the distinguished long-term survival outcome. Importantly, adjuvant chemotherapy may improve the 3-year overall survival for AJCC/CAP TRG1-3 category, whereas not for AJCC/CAP TRG0 category patients. Thus, AJCC/CAP TRG system, an accurate surrogate of long-term survival outcome, is useful in guiding adjuvant chemotherapy management for rectal cancer.
PMID: 33543577 [PubMed - as supplied by publisher]

Source: The Oncologist - February 4, 2021 Category: Cancer & Oncology Authors: Chen HY, Feng LL, Li M, Ju HQ, Ding Y, Lan M, Song SM, Han WD, Yu L, Wei MB, Pang XL, He F, Liu S, Zheng J, Ma Y, Lin CY, Lan P, Huang MJ, Zou YF, Yang ZL, Wang T, Lang JY, Orangio GR, Poylin V, Ajani JA, Wang WH, Wan XB Tags: Oncologist Source Type: research