Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver

This study indicated that the flow rate and bile acid in the perfused rat liver were key factors for bile flow rate and DF, DF-Glu, and DF-4′OH disposition in the absence of albumin.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research