Coronary Sinus Reducers and Internal Mammary Artery Occlusion: Giambattista Vico's Recurring Cycles within the History of Civilization

With great interest, I read the article by D'Amico et al1 reporting on the usefulness of a coronary sinus (CS) reducer, a percutaneous endo-luminal stent, for treating refractory angina. The principle behind implanting this device is focal narrowing in the lumen of the CS, which activates a short cascade of events. First, it creates a pressure gradient across the device, including an increase in backward pressure in venules and capillaries. Secondly, it causes microvascular blood redistribution from the less ischemic sub-epicardium to more ischemic endocardium, thereby adjusting the normal blood flow ratio between the heart's layers.

Source: The American Journal of Cardiology - February 5, 2021 Category: Cardiology Authors: Marco Picich è Source Type: research