The interleukin-1 family cytokines in psoriasis: pathogenetic role and therapeutic perspectives.

The interleukin-1 family cytokines in psoriasis: pathogenetic role and therapeutic perspectives. Expert Rev Clin Immunol. 2021 Feb 04;: Authors: Iznardo H, Puig L Abstract INTRODUCTION: IL-1 family cytokines play an important role in the innate immune system and their uncontrolled activation and expression can initiate a pathologic inflammatory response. Their role in psoriasis, pustular psoriasis and psoriatic arthritis has been studied, and offers potential interest as therapeutic targets. AREAS COVERED: This review focuses on the role that interleukin (IL)-1 family cytokines play in psoriasis pathogenesis, with a special focus in pustular psoriasis, and how these cytokines could be used as therapeutic targets. Using PubMed we reviewed the literature for articles related to IL-1 family cytokines and psoriasis, focusing on pustular psoriasis, and including pathogenesis, genetics and therapeutic targets. EXPERT OPINION: IL-1 and IL-36 cytokines act as critical drivers of autoinflammatory responses involved in pustular psoriasis. Studies on the specific role of each IL-1 cytokine are needed, as well as of their regulatory pathways. Targeting of IL-1 family cytokines has been used in pustular psoriasis, with IL-1 and IL-36R blockade showing promising results. PMID: 33538202 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research