Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.

CONCLUSION: Together with the finding that compounds 1 and 6 showed improved microsomal stability, these results suggest the translational potential of these putative Hsp70 inhibitors to foster new strategies for cancer therapy. However, whether these benzo-fused rhodacyanines act on kinases or other targets remains unclear, which is currently under investigation.
PMID: 33538660 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - February 3, 2021 Category: Chemistry Authors: Chang CS, Kumar V, Lee DY, Chen Y, Wu YC, Gao JY, Chu PC Tags: Curr Med Chem Source Type: research