The liver –alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels

Conclusions/interpretationWe reproduced the previously reported association of liver fat content and HOMA-IR with the glucagon –alanine index in an independent study cohort of young women with low to high risk for type 2 diabetes. Furthermore, our data indicates an insulin-resistance-independent association of liver fat content with the glucagon–alanine index. In summary, our study supports the concept that even lower l evels of liver fat (from 0.5%) are connected to relative hyperglucagonaemia, reflecting an imminent impairment of the liver–alpha cell axis.
Source: Diabetologia - Category: Endocrinology Source Type: research