Organ-specific Microcirculatory Mass Transport of Oxycodone in Humans: Clinical Implications for Therapeutic Use

Discussion: Organ-specific OC mass transport kinetics provide new information for OC dosing in pain management. The model promotes patient safety in opioid prescribing because it allows predictions to be made about the relative contribution that OC recycling makes to circulating OC levels. The model indicates that pharmacologic modulation of the microcirculation may give way to site-specific delivery of opioids in the future. Our study demonstrates that translation of bench in silico research data into clinical practice, although still challenging, is feasible and can assist in OC dose regimen design for patient safety.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research