The clinical and pathogenic spectrum of surgically-induced scleral necrosis: A review
The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis. All of them are poorly understood. Ocular trauma increasing lytic action of collagenases with subsequent collagen degradation, vascular disruption leading to local ischemia, and immune complex deposition activating the complement system represents some of the events that lead to scleral necrosis.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Raul E. Ruiz-Lozano, Lucas A. Garza-Garza, Osvaldo Davila-Cavazos, C. Stephen Foster, Alejandro Rodriguez-Garcia Tags: Major review Source Type: research