Lingual Seizures from Familial Cerebral Cavernous Malformations in a 4-year-old Child

Cerebral cavernous malformations (CCMs) are irregular clusters of dilated sinusoidal vessels in the brain, with up to 50% being familial1. Autosomal dominant mutations in KRIT1, CCM2, and PDCD10 account for 80% of familial cases2. Focal seizures are the presenting symptom in 50% of cases1. CCMs are best seen on magnetic resonance imaging (MRI) brain T2 gradient echo or T2 star-weighted angiography sequence.

Source: Pediatric Neurology - February 4, 2021 Category: Neurology Authors: Chethan K. Rao, Raj D. Sheth Source Type: research