Brain Derived Neurotrophic Factor in Neonatal Seizures

Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, has an extensively studied classical role in neuronal growth, differentiation, survival, and plasticity. Neurotrophic, from the Greek neuro and trophos, roughly translates as “vital nutrition for the brain.” During development, BDNF and its associated receptor tyrosine receptor kinase B (TrkB) are tightly regulated as they influence the formation and maturation of neuronal synapses. Preclinical research investigating the role of BDNF in neurological disorders has foc used on the effects of decreased BDNF expression on the development and maintenance of neuronal synapses.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research