Leucovorin rescue after methotrexate graft-vs-host disease prophylaxis shortens the duration of mucositis, time to neutrophil engraftment, and hospital length of stay

Oropharyngeal mucositis (OPM) is a common and often dose-limiting toxicity of allogeneic hematopoietic transplantation (alloHCT), resulting from chemotherapy or radiation-induced gastrointestinal mucosal toxicity.1 OPM results in pain, inadequate caloric intake, inability to take oral medications, gastrointestinal malabsorption, bleeding, and rarely airway compromise. Patients may require total parenteral nutrition (TPN) and parenteral opioid therapy, often in the form of patient-controlled analgesia (PCA) until recovery from OPM, which typically occurs at the time of neutrophil engraftment.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research