Doxorubicin ‐induced and trastuzumab‐induced cardiotoxicity in mice is not prevented by metoprolol

ConclusionA murine model of chronic cardiotoxicity induced by Dox and Trast was characterized by a decrease in cardiac function, a cardiac apoptosis and necrosis leading to cardiomyocyte atrophy. Metoprolol did not prevent this cardiotoxicity.

Source: ESC Heart Failure - February 2, 2021 Category: Cardiology Authors: Martin Nicol, Malha Sadoune, Evelyne Polidano, Jean Marie Launay, Jane Lise Samuel, Feriel Azibani, Alain Cohen ‐Solal Tags: Original Research Article Source Type: research