Could compensatory autoantibody production affect RA etiopathogenesis?

AbstractThe report from El ‐Gabalawy and coworkers represents an important chapter in their studies of rheumatoid arthritis (RA) in a unique First Nation (FN) patient cohort and their at‐risk first‐degree relatives (FDR)(1). These members of the Cree and Chippewa tribes in rural Manitoba Canada share racial/ethnic (and presumed genetic) features distinct from other RA cohorts. Here, the investigators show that during the preclinical phase, when patients were asymptomatic, these FN FDR express serum RA disease‐associated anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies and rh eumatoid factors (RFs).

Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Gregg J. Silverman Tags: EDITORIAL Source Type: research