Pure red cell aplasia and re ‐aggravation of myasthenia gravis as a result of early reduction of steroid and immunosuppressant after starting eculizumab: A case report

ConclusionsEculizumab might improve the acute phase of MG symptoms, but early reduction of PSL and TAC can aggravate MG pathology and lead to pure red cell aplasia. Autoimmune mechanisms other than the complement ‐mediated mechanism might be involved in the development of pure red cell aplasia. We suggest that physicians should not reduce PSL and immunosuppressants quickly after eculizumab administration.

Source: Clinical and Experimental Neuroimmunology - February 4, 2021 Category: Neurology Authors: Jun Yamazaki, Yuki Ueta, Yuki Akiba, Takeshi Taguchi, Masayuki Masuda, Hitoshi Aizawa Tags: CASE REPORT Source Type: research