The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products.

The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products. ChemMedChem. 2021 Feb 02;: Authors: Wang R, Zhou M, Ma HL, Li QS Abstract Chronic inflammation represents a long-term reaction of body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting non-resolving inflammation thus provides new opportunities for treating relevant diseases. In this review article, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain as a rich resource for discovery of new drugs treating chronic inflammation-associated diseases. PMID: 33528076 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research