A case of sustained antidepressant effects and large changes in the brain with a single brief exposure to nitrous oxide

We report the case of a 53-year-old woman with a history of recurrent depression and a current 2-year major depressive episode resistant to well-conducted escitalopram and venlafaxine therapy. She was included in the Protobrain study (NCT04199143 on clinicaltrials.gov), which consisted of exposing patients with treatment-resistant depression to 50% N20/50% O2 for 1 hour and investigating brain changes in response to the gas.

Source: The American Journal of Geriatric Psychiatry - February 3, 2021 Category: Geriatrics Authors: Thomas Desmidt, Val érie Gissot, Paul-Armand Dujardin, Frédéric Andersson, Laurent Barantin, Bruno Brizard, Nicolas Arlicot, Jean-Pierre Réméniéras, Fabien Espitalier, Wissam El-Hage, Vincent Camus Tags: Letter to the Editor Source Type: research