Type 1 Interferon –Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus

ConclusionWe identified a role for type I IFN signaling in driving STAT4 activation and production of IL ‐21 and IFNγ by Tfh cells in murine and human lupus. Enhanced STAT4 activation in Tfh cells may underlie pathogenic B cell responses in both murine and human lupus. These data indicate that STAT4 guides pathogenic cytokine and immunoglobulin production in SLE, demonstrating a potential therapeuti c target to modulate autoimmunity.

Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Xuemei Dong, Olivia Q. Antao, Wenzhi Song, Gina M. Sanchez, Krzysztof Zembrzuski, Fotios Koumpouras, Alexander Lemenze, Joe Craft, Jason S. Weinstein Tags: Full Length Source Type: research