Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling

ConclusionOur results provide new evidence that osteocytic TGF β signaling is required for a mechanosensitive response to injury, and that osteocytes control SBP homeostasis to maintain cartilage health, identifying osteocytic TGFβ signaling as a novel therapeutic target for OA.

https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41548?af=R

Source: Arthritis and Rheumatology - February 1, 2021 Category: Rheumatology Authors: Karsyn N. Bailey, Jeffrey Nguyen, Cristal S. Yee, Neha S. Dole, Alexis Dang, Tamara Alliston Tags: Full Length Source Type: research