REVERSE phenotyping —Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?

ConclusionAt the example of trait aggression, our results support the assumption that theTph2 null mutant mouse reflects theTPH2G ‐703T‐dependent phenotype in humans. Additionally, we conclude that “reverse phenotyping” is a promising method to validate experimental models and human findings for refined analysis of disease mechanisms.

Source: Brain and Behavior - February 1, 2021 Category: Neurology Authors: Atae Akhrif, Arunima Roy, Katharina Peters, Klaus ‐Peter Lesch, Marcel Romanos, Angelika Schmitt‐Böhrer, Susanne Neufang Tags: ORIGINAL RESEARCH Source Type: research