Drugmaker AbbVie reports 'strong' fourth-quarter and fiscal 2020 results

Strong sales of arthritis drug Humira and new Botox products helped in the quarter and fiscal year.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news

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AbstractFourteen constituents were recently isolated from the roots ofDendropanax dentiger with cyclooxygenase-2 (COX-2) inhibitory effects. However, the effect of 14 constituents on rheumatoid arthritis (RA) and their action mechanism remain unclear. The study aimed to explore the anti-RA effect and potential mechanism of these constituents in tumor necrosis factor α (TNF-α)–stimulated human RA fibroblast-like synoviocytes (MH7A cells). The cell viability, nitric oxide (NO) production, inflammatory cytokine levels, and protein expressions were measured by cell counting kit-8 (CCK-8), Griess reagent, ELIS...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
This study aimed to investigate the effects of quercetin (QT) and/or MX on inflammation and systemic toxicity in a rat model of RA. Male Wistar rats were divided into control (C), RA, QT, MX, and QT + MX groups (n=6). The RA induction consisted of three intra-articular injections of methylated bovine serum albumin (1 ×/week) in the temporomandibular joint (TMJ). QT (25 mg/kg) and/or MX (0.75 mg) administration occurred by oral gavage daily. We performed mechanical hyperalgesia in TMJ, leukocyte recruitment in synovial fluid, histopathology, and immunohistochemistry (TNF-α, IL-17, and IL-10) in synovial membran ...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
ARTHRITIS or other similar conditions that affect the joints, impacts more than 10 million people in the UK. The common condition causes pain and inflammation in a joint.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Brain Behav Immun. 2021 Sep 22:S0889-1591(21)00553-5. doi: 10.1016/j.bbi.2021.09.009. Online ahead of print.ABSTRACTInflammation is increasingly recognised to play a major role in gene-environment interactions in neurodevelopmental disorders (NDDs). The effects of aberrant immune responses to environmental stimuli in the mother and in the child can affect neuroimmune signalling that is central to brain development. Toll-like receptors (TLR) are the best known innate immune pattern and danger recognition sensors to various environmental threats. In animal models, maternal immune activation (MIA), secondary to inflammatory f...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Source Type: research
We present two hemodialysis patients with RA who presented with a complication of severe pancytopenia after treatment with MTX. After receiving various supportive and blood purification treatments, both patients recovered. We reviewed twenty-four pancytopenia patients on dialysis associated with methotrexate. Among these patients, high morbidity and mortality were observed, indicating that MTX should be used cautiously in the absence of alternatives in such a population. Compared with the patients who recovered, the deceased patients showed a lower level of leukocytes. Which dialysis method might be the best choice is uncl...
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Source Type: research
Arthritis Res Ther. 2021 Sep 24;23(1):246. doi: 10.1186/s13075-021-02623-7.ABSTRACTBACKGROUND: In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). As gut inflammation is commonly observed in axSpA patients, we performed a detailed analysis of monocyte transcriptomes of axSpA patients in two cohorts and searched for signs of activation and developmental adaptations as putative imprints of gut inflammation.METHODS: Transcriptomes of blood CD14+ monocytes of HLA-B27+ axSpA...
Source: Cell Research - Category: Cytology Authors: Source Type: research
In this study, we investigated the mechanism governing SM-induced cell death during differentiation into M1 macrophages and in polarized M1 macrophages. IFN-γ stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways. Interestingly, mTORC-1 regulated SM-induced cell death independent of M1 differentiation. In contrast, SM-induced cell death in polarized M1 macrophages is regulated by the mTORC-2 pathway. Moreover, SM-induced cell death is regulated by cellula...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
ARTHRITIS is a condition which roughly 10 million people are affected with. You could be unwittingly increasing your risk with any of these four habits.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ARTHRITIS is when the hard, slippery tissue that covers the ends of bones - where they form a joint - break down causing painful symptoms. These symptoms however can be reduced with these tips from the experts.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Patients with juvenile idiopathic arthritis (JIA) and TMJ involvement may have major dentofacial deformities, pain, and jaw dysfunction. The aim of this study was to evaluate surgical outcomes for JIA patients relative to TMJ pain, headache, jaw function, diet, disability, and quality of life (QOL) after TMJ reconstruction with patient-fitted total joint prostheses (TJP) and concomitant orthognathic surgery.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Craniomaxillofacial Deformitites/SleepDisorders/Cosmetic Sur Source Type: research
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