Epigenetic Regulation of Arginine Vasopressin Receptor 2 expression by PAX2 and Pax Transcription Interacting Protein.

In conclusion, PAX2 provides locus specificity for PTIP allowing the HMT complex to impart epigenetic changes at the Avpr2 locus and regulate Avpr2 transcription. These finding have major implications for understanding regulation of body water balance.
PMID: 33522413 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - February 1, 2021 Category: Physiology Authors: Abraham S, Paknikar R, Bhumbra S, Luan D, Venkatareddy M, O'Connor CL, Bitzer M, Fenton RA, Hurd T, Garg P, Patel SR Tags: Am J Physiol Renal Physiol Source Type: research