Low content of clonogenic progenitors on day+18 is associated with acute graft-versus-host disease and predicts transplant-related mortality

Graft-versus-host disease (GVHD) negatively affects marrow function [1,2]. Acute GVHD (a-GVHD) is associated with delay of initial platelet recovery [3] and secondary platelet failure [4]. In an experimental model in mice, the transplantation of haploidentical parental marrow into F1 recipients led to \impairment of marrow graft function in all lineages [5]. Osteoblastic damage was evident after the first week of transplantation, and myelosuppression was evident before signs of the development of a-GVHD in other organs [5].

Source: Experimental Hematology - January 11, 2021 Category: Hematology Authors: Giuseppe Milone, Paola Scir è, Maria Grazia Camuglia, Anna Triolo, Gaetano Moschetti, Maria Grazia Scuderi, Alessandra Cupri, Giulio Antonio Milone, Anna Bulla, Mary Ann Di Giorgio, Valerio Leotta, Angelo Curtopelle, Roberta Sciortino, Laura Parrinello, Source Type: research