Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles.

Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles.
Bioorg Med Chem Lett. 2021 Jan 28;:127809
Authors: Feliciano JA, Leitgeb AJ, Schrank CL, Allen RA, Minbiole KPC, Wuest WM, Carden RG
Abstract
Recent advances in the development of quaternary ammonium compounds (QACs) have focused on new structural motifs to increase bioactivity, but significantly less studied has been the change from ammonium- to sulfonium-based disinfectants. Herein, we report the synthesis of structurally analogous series of quaternary ammonium and trivalent sulfonium compounds (TSCs). The bioactivity profiles of these compounds generally mirror each other, and the antibacterial activity of sulfonium-based THT-18 was found to be comparable to the commercial disinfectant, BAC. The development of these compounds presents a new avenue for further study of disinfectants to combat the growing threat of bacterial resistance.
PMID: 33516911 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - January 28, 2021 Category: Chemistry Authors: Feliciano JA, Leitgeb AJ, Schrank CL, Allen RA, Minbiole KPC, Wuest WM, Carden RG Tags: Bioorg Med Chem Lett Source Type: research