Editorial: The Centrality of Both Hyper- and Hypo-Thalamocortical Connectivity in Psychosis

Long-standing hypotheses about schizophrenia as a “dysconnection” syndrome are consistent with the idea that mental illness arises in part from brain circuit disruptions, with impairments in cognition and behavior occurring because of a failure of coordinated action across multiple brain regions. One such theory, put forth by Andreasen and coll eagues, suggested that schizophrenia involves a disruption in the integration of cortical-striatal-thalamic-cerebellar circuits.1 Anatomical work in primates has shown that the thalamus is topographically organized into parallel pathways connecting specific thalamic nuclei to different regions of co rtex.

Source: Journal of the American Academy of Child and Adolescent Psychiatry - February 2, 2021 Category: Psychiatry Authors: Deanna M. Barch Tags: Editor's Note Source Type: research