Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU

February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said Craig Tendler, M.D., Vice President, Clinical Development and Global Medical Affairs, Janssen Research &Development, LLC. “This year, we look forward to presenting data from our robust prostate cancer development program, including analyses of the Phase 3 ACIS and TITAN studies, which underscore the clinical value of our portfolio for patients today and set the stage for the next generation of therapies in our pipeline.”New Analyses for ERLEADA® Highlight Breadth of Ongoing Clinical Development ProgramData from three Phase 3 registrational clinical trials will be featured in oral presentations:ACIS: Analysis evaluating ERLEADA® (apalutamide) in combination with ZYTIGA® (abiraterone acetate) plus prednisone versus abiraterone acetate plus prednisone in patients with chemo-naïve metastatic castration-resistant prostate cancer (Ab...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Our Company Source Type: news

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Contributors : Weilin Pu ; Xiao Shi ; Pengcheng Yu ; Meiying Zhang ; Xiaoming Zhang ; Yulong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profiled transcriptomes of 158,577 cells from 11 patients ’ paratumors, localized/advanced tumors, initially-treated/recurrent lymph nodes and radioactive iodine (RAI)-refractory distant metastases, covering comprehensive clinical courses of PTC.Our study illuminates a comprehensive landscape of PTC ecosystem that sugge...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Just went to a skills lab and they divided us into small groups. Before beginning each skills session, when asked what your primary specialty was, if the person teaching the skill was from an anesthesiology background, more times than not if you answered something other than anesthesia, the proctor would say something similar to "Well I guess you didn't get any training in this in residency". This included a session on suturing after procedures such as SCS or pumps. Not saying all those... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
This study investigated the effects of 12 wk of postexercise kefir consumption in cancer survivors who have undergone chemotherapy and/or radiation therapy. Methods All participants were enrolled in a structured exercise training program and separated into kefir (KEF) or control (CON) treatment groups. KEF consumed 8 oz. of kefir after exercise sessions (3 d·wk−1) for 12 wk. Outcome measures included assessments for body size and composition, aerobic fitness and muscular strength, medical history, and psychological state at pre- and postintervention time points. Blood was collected and analyzed for C-re...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Conclusions Exercise training combined with multinutrient supplementation had a limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Purpose The current study investigated the effects of unilateral passive stretching on the neuromuscular mechanisms involved in the force-generating capacity of the contralateral muscle. Methods Twenty-six healthy men underwent unilateral passive stretching of the plantarflexors (5 × 45 s on + 15 s off; total stretching time, 225 s). Before and after the stretching protocol, contralateral ankle range of motion, maximum voluntary contraction (MVC) of the plantarflexors, and surface electromyographic root-mean-square (sEMG RMS) of the soleus and the gastrocnemii muscles were determined. Concurrently, V-wave,...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: BASIC SCIENCE Source Type: research
Conclusion These findings demonstrate that T2D and HTN attenuate tolerance to uncompensable heat stress (32°C WBGT); however, these chronic diseases do not significantly impact thermal and cardiovascular strain, or the validity of ACIGH recommendations during moderate-intensity work.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Conclusion Chronic exercise seems to prime the central nervous system for acute, intensive bouts of exercise. Our findings indicate a possible relationship between cognitive performance in high-demand tasks and retinal vasculature and support the idea of a neuroplastic effect of exercise.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
I am working on transcript repair because of too many withdrawals from now-resolved health issues. I had an off-start to the semester but am doing better. That said, I think there's a good chance I am going to get B's in two of my classes. Both of them science. :/ One of them Organic Chemistry. I've gotten all A's until now in my transcript repair. I was under the impression that I had to and a B would detract from the transcript repair. Is just a couple of B's okay even in the context of... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical (MD) Source Type: forums
In conclusion, this survey raises the awareness of the discordances and serves as a starting point towards further standardization of the pancreatoduodenectomy grossing and reporting protocols.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
In conclusion, the vast majority of the GIM samples (98%) lack the aneuploidy that is characteristic of gastric dysplasia or cancer. This indicates that aneuploidy usually occurs after the development of gastric dysplasia rather than at the stage of GIM. The finding also suggests that the presence of GIM alone may not be sufficient to suggest an increased risk for GC and that the inclusion of other high-risk features (ie, extensive GIM, dysplasia, racial minorities, and/or family history of GC in a first-degree relative) and/or aneuploidy ought to play a role in the selection of GIM patients who may warrant endoscopic surv...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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