Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU
February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said Craig Tendler, M.D., Vice President, Clinical Development and Global Medical Affairs, Janssen Research &Development, LLC. “This year, we look forward to presenting data from our robust prostate cancer development program, including analyses of the Phase 3 ACIS and TITAN studies, which underscore the clinical value of our portfolio for patients today and set the stage for the next generation of therapies in our pipeline.”New Analyses for ERLEADA® Highlight Breadth of Ongoing Clinical Development ProgramData from three Phase 3 registrational clinical trials will be featured in oral presentations:ACIS: Analysis evaluating ERLEADA® (apalutamide) in combination with ZYTIGA® (abiraterone acetate) plus prednisone versus abiraterone acetate plus prednisone in patients with chemo-naïve metastatic castration-resistant prostate cancer (Ab...
Prevalences, nuances of presentation, and likely clinical course of myocarditis after use of some vaccines against SARS-CoV-2 are in sharper view after additions to the literature this week.Medscape Medical News
Immune checkpoint inhibitors can be effective in patients with non-small cell lung cancer and mild interstitial lung disease, but with a greater risk.Medscape Medical News
We thank the respondents to our article1 for their insightful comments. Although we have matched subjects in both cohorts by age, sex, comorbidities, and index date, Lin et al2 indicate a lack of adjustment for co-medication status, including the use of corticosteroids and disease-modifying antirheumatic drugs (DMARDs), in the propensity score. We agree that these medications are important confounders on fracture. We therefore had conducted multivariate analysis in t he published article by adjustment for corticosteroids, DMARDs, and phototherapy.
AbstractPurposeGenetic variants may influence the pharmacokinetics and pharmacodynamics (PKPD) of cyclophosphamide (CY). CY plays a critical role in conditioning chemotherapy for hematopoietic cell transplantation (HCT), but its use is limited by toxicity. We explored the effect of genetic variants, potentially affecting PKPD of CY, and outcomes after HCT.MethodsThis observational pharmacogenomic study included 85 adults with hematologic malignancies who received reduced intensity conditioning with CY, fludarabine, and total body irradiation. We collected recipient DNA prior to HCT and evaluated 97 candidate variants in 66...
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02158-wSELENOF is a new tumor suppressor in breast cancer
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00651-zMalignant hypertension and atypical hemolytic uremic syndrome: a possible continuum between two entities?
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00652-yFocus on today’s evidence while keeping an eye on the future: lessons derived from hypertension in women
Org. Biomol. Chem., 2022, Advance Article DOI: 10.1039/D1OB02294F, CommunicationShan Shan Ng, Zicong Chen, On Ying Yuen, Chau Ming So A novel family of indole-amide-based phosphine ligands was designed and synthesized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Prasad Rama, Zareen Abbas The role of silica nanoparticle shape in the interaction of PHTHA organic molecules onto the spheroid and cuboid geometrical interfaces at various aqueous environments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
New J. Chem., 2022, Advance Article DOI: 10.1039/D1NJ05347G, PaperDivyamahalakshmi Muthuraj, Raja Murugan, Pavul Raj Rayappan, Ganapathi Rao Kandregula, Kothandaraman Ramanujam A freestanding magnesium aluminate ceramic separator can inhibit the shuttling of polysulfides by chemical adsorption, thereby improving the electrochemical performance of the Li –S battery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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