MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak.

Conclusions: Moderate MCU overexpression in failing hearts enhances contractility and responses to β-adrenergic stimulation in isolated myocytes and perfused hearts by inhibiting mitochondrial oxidative stress-induced SR Ca2+ leak. MCU overexpression also reversed HF and inhibited ectopic ventricular arrhythmias. PMID: 33522833 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33522833?dopt=Abstract

Source: Circulation Research - February 1, 2021 Category: Cardiology Authors: Liu T, Yang N, Sidor A, O'Rourke B Tags: Circ Res Source Type: research