Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human

T- and B-lymphocyte developmental processes have enjoyed particularly in-depth characterization [1 –6]. However, relatively little knowledge concerning T cells has been integrated into current discussions of broader hematopoietic differentiation. Most single-cell transcriptome analyses of multilineage hematopoietic stem and progenitor cells, while powerful and sophisticated [7–12], have under characterized lymphoid precursors. Cells starting the B-cell and natural killer (NK) cell programs are detected in bone marrow and are often labeled as general “lymphoid” precursors [13–15], but benchmarks for initiation of the T-cell program have been lacking.

Source: Experimental Hematology - January 13, 2021 Category: Hematology Authors: Ellen V. Rothenberg Tags: Invited Review Source Type: research