Reduced Thalamic Volume and Metabolites in Type 1 Diabetes with Polyneuropathy

Conclusions In this cohort with type 1 diabetes and severe DSPN, thalamic atrophy was present and associated with reduced NAA/cre, indicating thalamic structural loss and dysfunction. Thalamic atrophy was associated to reduced sensory function involving large fiber neuropathy and sensation to tetanic stimulation that may reflect synaptic transmission. This may ultimately contribute to the current understanding of the pathophysiology behind the perception changes evident in DSPN. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Experimental and Clinical Endocrinology and Diabetes - February 1, 2021 Category: Endocrinology Authors: Hansen, Tine M. Fr økjær, Jens B. Selvarajah, Dinesh Muthulingam, Janusiya A. Tesfaye, Solomon Juhl, Anne Drewes, Asbj ørn M. Jakobsen, Poul E. Karmisholt, Jesper Brock, Birgitte Brock, Christina Tags: Article Source Type: research