Malaria and the Blood-Brain Barrier

 EPCR and ICAM ReceptorsNeuromicsAstrocytes and Pericytes were used in this important study-Yvonne Adams, Rebecca W. Olsen, Anja Bengtsson, Nanna Dalgaard, Mykola Zdioruk, Sanghamitra Satpathi, Prativa K. Behera, Praveen K. Sahu, Sean E. Lawler, Klaus Qvortrup, Samuel C. Wassmer, and Anja T.R. Jensen. (2021).Plasmodium Falciparum Erythrocyte Membrane Protein 1 Variants Induce Cell Swelling and Disrupt the Blood –Brain Barrier in Cerebral Malaria. Journal of Experimental Medicine, 218 (3). doi: 10.1084/jem.20201266.This is the first study showing malaria pericytes interacting with human endothelial cells. Please note we have the completeBBB Model that can be used for studies like these.
Source: Neuromics - Category: Neuroscience Tags: 3-D Blood-Brain Barrier Model –brain barrier penetration brain microvascular endothelial cells human Astrocytes Human Endothelial Cells Human Pericytes Source Type: news