Oncotarget: Simvastatin is a potential candidate drug in ovarian clear cell carcinomas

(Impact Journals LLC) " Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC. "
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionEndometriosis was not independently associated with the prognosis of OCCC either in crude analysis or after stratification for stage and RD. Further larger, well-designed prospective studies are warranted to draw firmer conclusions on the intrinsic link between endometriosis and OCCC.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
CONCLUSIONS: CCC represents hypercoagulable disease and elevate D-dimer is a prognostic factor for decreased survival in CCC. D-dimer high CCC has distinct molecular characteristics into the inflammatory-driven pathway (hot tumor) and the immune-suppressive pathway (cold tumor). Treatment implication of our proposed molecular classification merits further investigation.PMID:34452748 | DOI:10.1016/j.ygyno.2021.08.009
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Survival was not compromised when primary laparoscopic surgery was performed in early-stage OCCC patients. A well-designed randomized controlled trial is warranted.PMID:34421313 | PMC:PMC8372305 | DOI:10.2147/CMAR.S321173
Source: Cell Research - Category: Cytology Authors: Source Type: research
Source: Acta Clinica Belgica - Category: General Medicine Authors: Source Type: research
Oncol Lett. 2021 Sep;22(3):650. doi: 10.3892/ol.2021.12911. Epub 2021 Jul 9.ABSTRACTOvarian cancer affects>295,000 women worldwide and is the most lethal of gynaecological malignancies. Often diagnosed at a late stage, current research efforts seek to further the molecular understanding of its aetiopathogenesis and the development of novel biomarkers. The present study investigated the expression levels of the glucogenic hormone asprosin [encoded by fibrillin-1 (FBN1)], and its cognate receptor, olfactory receptor 4M1 (OR4M1), in ovarian cancer. A blend of in silico open access The Cancer Genome Atlas data, as well as i...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
This study showed that KP extract inhibited interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production at both transcription and translation levels via the suppression of nuclear factor-kappa B (NF-κB) signal transduction. In contrast, KP extract increased the expression of inhibitor kappa B (IκB) protein which may delay NF-κB translocation into the nucleus upon TNF-α activation. Moreover, the suppression of cytokines released from KP treated-TOV-21G reduced the migration of monocyte cell (THP-1). KP extract also exhibited the inhibition of IL-6 and MCP-1 production from THP-1 ac...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
Fenwick Nik Matthews Michael J. F. Hubank Christopher J. Lord Syed Haider Alan Melcher Susana Banerjee Rachael Natrajan Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumoural T cell response has been reported in a subset of OCCC, with ARID1A purported to be a biomarker for the response to the immune checkpoint blockade independent of micro-satellite instability (MSI). However, assessment of the different imm...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, we analyzed the correlation between global miRNA and mRNA expression patterns derived from microarray profiling of 19 7 EOC patients to identify the signatures of miRNA-mRNA interactions associated with overall survival (OS). The aim was to investigate whether these miRNA-mRNA signatures might have a prognostic value for OS in different subtypes of EOC. The content of our cohort (162 serous carcinomas, 15 endometri oid carcinomas, 11 mucinous carcinomas, and 9 clear cell carcinomas) reflects a real-world scenario of EOC. Several interaction pairs between 6 miRNAs (hsa-miR-126-3p, hsa-miR-223-3p, hsa-miR-23a-...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Vaccine. 2021 Jul 20:S0264-410X(21)00879-3. doi: 10.1016/j.vaccine.2021.07.020. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG), a vaccine intended to protect against tuberculosis disease, can elicit protection against heterologous infections, and even specific types of cancer. In this mini-review, we will address the possible use of BCG as a therapeutic for endometriosis, a syndrome of chronic pelvic pain due to ectopic growth of endometrial-type tissue outside of the uterine lining. These implanted tissues cycle synchronously with menses in pre-menopausal women, generating cellular debris inciting chro...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Authors: Arildsen NS, Hedenfalk I Abstract Ovarian clear cell carcinomas (OCCC) constitute a rare subtype of epithelial ovarian cancer, lacking efficient treatment options. Based on previous studies, we assessed the anti-proliferative effect of simvastatin, a Rho GTPase interfering drug, in three OCCC cell lines: JHOC-5, OVMANA and TOV-21G, and one high-grade serous ovarian cancer (HGSOC) cell line, Caov3. We used the Rho GTPase interfering drug CID-1067700 as a control. All OCCC cell lines were more sensitive to single-agent simvastatin than the HGSOC cells, while all cell lines were less sensitive to CID-1067700 ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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