Cellular signalling crosstalk between different cardiac cell populations - An insight into the role of exosomes in the heart diseases and therapy.

Cellular signalling crosstalk between different cardiac cell populations - An insight into the role of exosomes in the heart diseases and therapy. Am J Physiol Heart Circ Physiol. 2021 Jan 29;: Authors: Nguyen BY, Azam T, Wang X Abstract Exosomes are a subgroup of extracellular bilayer membrane nanovesicles that are enriched in a variety of bioactive lipids, receptors, transcription factors, surface proteins, DNA and noncoding RNAs. They have been well-recognised to play essential roles in mediating intercellular signalling by delivering bioactive molecules from host cells to regulate the physiological processes of recipient cells. In the context of heart diseases, accumulating studies have indicated that exosome-carried cellular proteins and noncoding RNA derived from different types of cardiac cells, including cardiomyocytes, fibroblasts, endothelial cells, immune cells, adipocytes and resident stem cells have pivotal roles in cardiac remodelling under disease conditions such as cardiac hypertrophy, diabetic cardiomyopathy and MI. In addition, exosomal contents derived from stem cells have been shown to be beneficial for regenerative potential of the heart. In this review, we will discuss current understanding of the role of exosomes in cardiac communication, with a focus on cardiovascular pathophysiology and perspectives for their potential uses as cardiac therapies. PMID: 33513083 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research