IL-1 β promotes disk degeneration and inflammation through direct injection of intervertebral disk in a rat lumbar disk herniation model

Lumbar intervertebral disk herniation (LDH) is a common disease that causes low back pain, radiating leg pain, and sensory impairment. Preclinical studies rely heavily upon standardized animal models of human diseases to predict clinical treatment efficacy and to identify and investigate potential adverse events in human subjects. The current method for making the LDH model involves harvesting the nucleus pulposus (NP) from autologous coccygeal disks and applying to the lumbar nerve roots just proximal to the corresponding dorsal root ganglion.
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Basic Science Source Type: research