Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.

CONCLUSIONS: ChGn-2 alteration on macrophages conceivably influences LDL accumulation and subsequently accelerates plaque formation. These results collectively suggest that ChGn-2 is a novel therapeutic target amenable to clinical translation in the future. PMID: 33504177 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33504177?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 28, 2021 Category: Cardiology Authors: Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata KI, Emoto N Tags: Arterioscler Thromb Vasc Biol Source Type: research