The role of micropeptides in biology.

The role of micropeptides in biology.
Cell Mol Life Sci. 2021 Jan 28;:
Authors: Vitorino R, Guedes S, Amado F, Santos M, Akimitsu N
Abstract
Micropeptides are small polypeptides coded by small open-reading frames. Progress in computational biology and the analyses of large-scale transcriptomes and proteomes have revealed that mammalian genomes produce a large number of transcripts encoding micropeptides. Many of these have been previously annotated as long noncoding RNAs. The role of micropeptides in cellular homeostasis maintenance has been demonstrated. This review discusses different types of micropeptides as well as methods to identify them, such as computational approaches, ribosome profiling, and mass spectrometry.
PMID: 33507325 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 28, 2021 Category: Cytology Authors: Vitorino R, Guedes S, Amado F, Santos M, Akimitsu N Tags: Cell Mol Life Sci Source Type: research