Reduced-dose RT with Cisplatin improves outcomes for HPV-associated oropharyngeal carcinoma

(NRG Oncology) A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease control and quality of life compared to the standard of care for good-risk patients with HPV-associated oropharyngeal squamous cell carcinoma on the NRG Oncology clinical trial NRG-HN002.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Radiation plays an important role in the definitive treatment of various head and neck cancers.(1-3) Conventional techniques of radiotherapy result in high rates of late effects, such as dysphagia, radionecrosis, and xerostomia. The physical dose distributions over the target volume and nearby surrounding structures has improved with the advancement of radiation therapy techniques and specifically the adoption of intensity-modulated radiotherapy (IMRT) coupled with image guidance.(4) This has led to decreased toxicity rates, especially xerostomia.(5) In a recent study of patients receiving modern techniques of IMRT with or...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Neck dissection prior to definitive chemoradiotherapy in N2-3 oropharyngeal squamous cell carcinoma was associated with high neck control without additional mid and long-term morbidity.PMID:34175226 | DOI:10.1016/j.canrad.2021.05.007
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Source Type: research
Opinion statementThe rise in the incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPC), the relatively young age at which it is diagnosed, and its favorable prognosis necessitate the use of treatment techniques that reduce the likelihood of side effects during and after curative treatment. Intensity-modulated proton therapy (IMPT) is a form of radiotherapy that de-intensifies treatment through dose de-escalation to normal tissues without compromising dose to the primary tumor and involved, regional lymph nodes. Preclinical studies have demonstrated that HPV-positive squamous cell ca...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
This phase I study assessed the safety of first-in-class radioenhancer nanoparticles, NBTXR3, in elderly or frail patients with locally advanced head and neck squamous cell carcinoma (HNSCC), ineligible for chemoradiation.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
The required elective nodal dose and volumes for head and neck intensity-modulated radiotherapy (IMRT) have largely been extrapolated from conventional radiotherapy fields. In this prospective, dual-center, phase II study, we investigated the efficacy and tolerability of reduced elective nodal volume and dose in oropharyngeal and laryngeal squamous cell carcinoma (SqCC).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The required elective nodal dose and volumes for head and neck intensity modulated radiation therapy have largely been extrapolated from conventional radiation therapy fields. In this prospective, dual-center, phase 2 study, we investigated the efficacy and tolerability of reduced elective nodal volume and dose in oropharyngeal and laryngeal squamous cell carcinoma.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Scientific Letters Source Type: research
CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients ’ response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.
Source: Clinics - Category: General Medicine Source Type: research
Radiotherapy (RT) is a standard treatment for oropharyngeal cancer (OPC), regardless of human papilloma virus (HPV) status. The prevalence of HPV-associated squamous cell carcinoma of the oropharynx is rising, especially in relatively young, otherwise healthy individuals [1,2]. Substantial advances have been made to reduce RT-related toxicity to match the high curability of this disease with improved survivorship. However, even with the advanced dose conformality provided by intensity modulated radiotherapy (IMRT), treatment remains considerably toxic with long-term sequelae, such as xerostomia, dysgeusia, dysphagia, malnu...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
AbstractObjectiveTo evaluate treatment outcomes after definitive chemoradiotherapy (CRT) for human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC).Materials and methodsWe analyzed data concerning HPV-negative OPSCC patients treated with curative intent. All patients received concomitant high-dose cisplatin-based chemotherapy. Two different RT techniques were used: (1) sequential boost IMRT (S-IMRT) to a total dose of 70  Gy (2 Gy/fraction); (2) simultaneously integrated boost (SIB-IMRT) to a total dose of 67.5 Gy (2.25 Gy/fraction). Survival outcomes were estimated.ResultsIn...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Oropharynx Cancer;   Oropharynx Squamous Cell Carcinoma;   Carcinoma, Squamous Cell;   Carcinoma;   Oropharyngeal Neoplasms;   Neoplasms, Squamous Cell;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Pharyngeal Neoplasms Malignant and Unspecif ied;   Otorhinolaryngologic Neoplasms;   Head and Neck Neoplasms;   Neoplasms by Site;   Otorhinolaryngologic Diseases;   Pharyngeal Diseases...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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