Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence.

Conclusions: This study provides the first evidence that the cardiac proteome and phosphoproteome are significantly altered post pulmonary influenza infection. Moreover, viral particles can persist in the heart after lung clearance, altering mitochondrial function and promoting cell death without active replication and interferon responses. Finally, our findings show inhibition of necroptosis or prevention of mitochondrial damage as possible therapeutic interventions to reduce cardiac damage during influenza infections.
PMID: 33501852 [PubMed - as supplied by publisher]

Source: Circulation Research - January 27, 2021 Category: Cardiology Authors: Lin YH, Platt M, Gilley RP, Brown D, Dube PH, Yu Y, Gonzalez-Juarbe N Tags: Circ Res Source Type: research