Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy

Obesity-driven cardiac lipid accumulation can progress to lipotoxic cardiomyopathy. Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism. The current study explores the unknown role of sEH deficiency in lipotoxic cardiomyopathy and its underlying mechanism. Wild-type and Ephx2 knock out (sEH KO) C57BL/6  J mice were fed with high-fat diet (HFD) for 24 weeks to induce lipotoxic cardiomyopathy animal models.

Source: Journal of Molecular and Cellular Cardiology - December 27, 2020 Category: Cytology Authors: Luyun Wang, Daqiang Zhao, Liangqiu Tang, Huihui Li, Zhaoyu Liu, Jingwei Gao, Matthew L. Edin, Huanji Zhang, Kun Zhang, Jie Chen, Xinhong Zhu, Daowen Wang, Darryl C. Zeldin, Bruce D. Hammock, Jingfeng Wang, Hui Huang Source Type: research