Aging in reverse: Reactivating developmental signaling for cardiomyocyte proliferation

Mammalian heart is considered postmitotic with limited cardiomyocyte (CM) turnover during lifetime of an individual [1]. Adult CMs are typically unable to complete the cell cycle and respond to growth signals by hypertrophy or incomplete cytokinesis resulting in binucleation and/or polyploidization, considered to be major hurdles in CM proliferation and regeneration [2]. Ensuing years have seen a tremendous effort to delineate CM cell cycle and develop strategies that promote cell cycle reentry and CM mediated regeneration of the heart following injury.

Source: Journal of Molecular and Cellular Cardiology - January 15, 2021 Category: Cytology Authors: Vagner Oliveira Carvalho Rigaud, Mohsin Khan Tags: Short communication Source Type: research