Comparative pharmacodynamics of echinocandins against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model that correlates with clinical response to caspofungin therapy: Is there a place for dose optimization?

Conclusions. Among the three echinocandins, only caspofungin at two-three times licensed dosing was associated with a high PTA. Caspofungin dose escalation might deserve clinical validation. PMID: 33495222 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33495222?dopt=Abstract

Source: Antimicrobial Agents and Chemotherapy - January 25, 2021 Category: Microbiology Authors: Siopi M, Perlin DS, Arendrup MC, Pournaras S, Meletiadis J Tags: Antimicrob Agents Chemother Source Type: research