Biomarkers of chronic spontaneous urticaria and their clinical implications.

Biomarkers of chronic spontaneous urticaria and their clinical implications. Expert Rev Clin Immunol. 2021 Jan 26;: Authors: Asero R, Cugno M Abstract Introduction: Chronic spontaneous urticaria (CSU) is a frequent disorder in which activation of effector cells and histamine release can be induced via several distinct pathogenetic mechanisms. Much work has been carried out to identify biomarkers useful to classifying CSU patients, and to predict their response to currently available treatments. Areas covered: The recent literature dealing with CSU biomarkers was screened in PubMed and Google Scholar using "chronic spontaneous urticaria", "biomarker", "diagnosis", "therapy" and "treatment response" as key words. The characteristics found in relevant papers were divided into clinical and serological biomarkers of a) clinical severity/disease activity, and b) response to treatments. Expert opinion: A diagnostic biomarker for CSU is still missing. Most biomarkers described so far do not seem to possess sufficient specificity for this disease. Several studies suggest that basopenia might be a biomarker but information available so far is insufficient to consider its routine use. Similarly, although the activation of the coagulation cascade (which is easily measurable by D-dimer plasma levels) is detected in about 50% of patients with severe CSU and seems to identify patients that are antihistamine- and cyclosporine-resistant we do not hav...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research